Scientific Program

Day 1, Wednesday 7th November 2018

7:00-8:30 Registration
8:30-8:45 Welcome Speeches (Opening Ceremony)
8:30-8:35 Dr. Khalid S. A. Khabar, PhD
Deputy Executive Director, Research Centre, KFSH&RC
8:35-8:40 H.E. Dr. Majid AlFayyadh, MD, MMM
Chief Executive Officer, KFSH&RC
8:40-8:45 HRH Princess Haifa AlFaisal
President of Zahra Breast Cancer Association
8:45-9:05 Exhibitions/Posters
9:05-10:15 Epidemiology/Pathology: Facts and Challenges
Moderator Dr. Mohammad Al-Shabanah
9:05-9:35 Keynote Speaker: Dr. Neil M. Iyengar, MD; Memorial Sloan Kettering Cancer Center, New York, USA
“Obesity and Breast Cancer: The role of energy homeostasis and adiposity”
9:35-9:55 Speaker: Dr. Asma Tulba, MD, FRCPA; KFSH&RC, Riyadh, Saudi Arabia
"The molecular basis of breast cancer pathological phenotypes”
9:55-10:15 Speaker: Dr. Maria Arafa, MD; King Saud University, Riyadh, Saudi Arabia
“The epidemiology of Breast cancer in Saudi Arabia & updated concepts in breast pathology”
10:15-10:45 Poster Session / Coffee Break
10:45-12:15 Genomics/Proteomics: Principles and Clinical Applications
Moderator Dr. Ghazi AlSbeih
10:45-11:15 Keynote Speaker:Dr. Balázs Győrffy, MD, PhD, DSc; Hungarian Academy of Sciences, Budapest, Hungary
“Employing genomic data to validate new biomarkers in solid tumors"
11:15-11:35 Speaker: Dr. Abdul Khalid Siraj, PhD; KFSH&RC, Riyadh, Saudi Arabia
“Identification of Novel BRCA Founder Mutations in Middle Eastern Breast Cancer Patients
Using Capture ad Sanger Sequencing Analysis”
11:35-11:55 Speaker: Dr. Nisreen Al-Moghrabi, PhD; KFSH&RC, Riyadh, Saudi Arabia
“Constitutional methylation and breast cancer predisposition”
11:55-12:15 Speaker: Dr. Ayodele Abdelkarim Alaiya, PhD, MB.BS, MPH, FRCPath; KFSH&RC, Riyadh, Saudi Arabia
“Clinical Proteomics: Promises and Challenges of Translating Benchtop Discovery into Bedside Application”
12:15-13:30 Lunch Break
13:30- 15:00 Tumor Microenvironment:
Moderator Dr. Neil M. Iyengar
13:30-14:00 Special Presentation: Dr. Abdelilah Aboussekhra, PhD; KFSH&RC, Riyadh, Saudi Arabia
“Role of Tumor Microenvironment and cellular plasticity in breast carcinogenesis”
14:00-14:30 Keynote Speaker: Dr. Hasan Korkaya, DVM., PhD; Augusta University, Georgia, USA
“Clinical implications and opportunities of immune regulated breast cancer stem cell plasticity”
14:30-14:50 Speaker: Dr. Huda Al-Khalaf, PhD; KACST, KFSH&RC, Riyadh, Saudi Arabia
“Obesity and Breast Cancer: The role of the microenvironment”
14:50-15:00 Short Talk: Dr. Layla AA AL-Kharashi, PhD, College of Pharmacy, KSU, Riyadh, Saudi Arabia
“Eugenol suppresses DNMT1 and normalizes breast cancer-associated fibroblast”
15:00-15:10 Short Talk: Ms. Bothina Mohammed AlHarbi, MSc, KAIMRC, Riyadh, Saudi Arabia
“Let-7b inhibits cancer-promoting effects of breast cancer-associated fibroblasts through IL-8 repression”
15:10-15:30 Coffee Break
15:30- 17:00 CDK4/6 inhibitors: a Changing Paradigm
Moderators Dr. Dahish Ajarim and Dr. Omalkhair Abulkhair
15:30-16:00 Keynote Speaker: Prof. Jean-Marc A. Nabholtz, MD, PhD; King Saud University Medical City, Riyadh, Saudi Arabia
“The Growing role of CDK4/6 inhibitors in treating hormone receptor-positive advanced breast cancer-The biology background”
16:00-16:20 Speaker: Dr. Taher Al-Tweigeri, MD, MBBch, FRCPC; KFSH&RC, Riyadh, Saudi Arabia
“Molecular mechanisms of endocrine resistance: The clinic impact”
16:20-16:40 Speaker: Dr. Ahmed Saad Eddin, MD, FRCR (UK); King Abdulaziz Medical City, Riyadh, Saudi Arabia
“Present Revolution and Future Evolution of the management of luminal breast cancer”
16:40-17:00 Zahra BC Association

Day 2, Thursday 8th November 2018

7:30-8:30 Poster Session/Breakfast
8:30-10:00 Breast Cancer Biomarkers: Towards Targeted Therapy
Moderators Dr. Gilles Pages and Dr. Suad M. Ben Amer
8:30-9:00 Special Presentation: Dr. Khalid S. A. Khabar, PhD; KFSH&RC, Riyadh, Saudi Arabia
“Deficiency of the zinc finger binding protein, tristetraprolin, is a hallmark of cancer”
9:00-9:30 Keynote Speaker: Dr. Gilles Pages, PhD; University of Nice Sophia Antipolis, France
"Resistance to lysosomotropic drugs used for kidney and breast cancers involves autophagy and inflammation and converges in inducing CXCL5”
9:30-9:50 Speaker: Dr. Amal Qattan, PhD; KFSH&RC, Riyadh, Saudi Arabia
“MicroRNAs: Puzzling molecules in Cancer Therapy... Are we ready?
9:50-10:00 Short Talk: Ms. Manar AlAhmari, BSc, KFSHRC, Riyadh, Saudi Arabia
"The RNA-binding protein AUF-1 induces stemness in breast cancer cells”
10:00-10:10 Short Talk: Dr. Homood Moqbel As Sobeai, PhD, College of Pharmacy, KSU, Riyadh, Saudi Arabia
"Targeting nucleotide excision repair by miR-145 in breast cancer; a novel therapeutic strategy to overcome chemotherapy resistance”
10:10-10:15 Breast Cancer Survivor (Zahra)
10:15-10:45 Poster Session / Coffee Break
10:45-12:15 Cancer Stem Cells: Towards Cancer Eradication from Roots
Moderators Dr. Mohammed Abumaree and Dr. Abdelali Haoudi
10:45-11:15 Keynote Speaker: Dr. Robert Clarke, PhD; The University of Manchester, UK
“Regulation of breast cancer stem cell activity by the bone metastatic niche"
11:15-11:35 Speaker: Dr. Monther Al-Alwan, PhD; KFSH&RC, Riyadh, Saudi Arabia
“Cancer stem cell targeted therapy: Hope or hype”
11:35-11:55 Speaker: Dr. Syed Islam, PhD; KFSH&RC, Riyadh, Saudi Arabia
“Eugenol potentiates cisplatin anti-breast cancer stem cells”
11:55-12:05 Short Talk: Ms. Noura Alraouji, BSc, KFSHRC Riyadh, Saudi Arabia
“Tocilizumab (anti-IL-6R): a potential targeted therapy for triple-negative breast cancer”
12:05-12:15 Short Talk: Ms. Rayyanah Y. Barnawi, MSc, KFSHRC, Riyadh, Saudi Arabia
“Fascin Regulates β1 Integrin to Maintain Breast Cancer Stem Cells by Stimulating Gsk-3β Signaling Pathway”
12:15-13:30 Lunch Break
13:30- 16:00 Cancer NanoMedicine and Immunotherapy: Prospects and Challenges
Moderators Dr. Shouki Bazarbashi and Dr. Alhassan H. Aodah
13:30-14:00 Keynote Speaker: Dr. Alexander V. Kabanov, PhD, Dr.Sc., M.A.E., FNAI, FAIMBE; University of North Carolina, Chapel Hill, USA
“Hyperloaded Poly(2-oxazoline) Micelles as Drug Carriers for Cancer Therapy”
14:00-14:20 Speaker: Dr. Ali Alhasan, PhD; KACST, Riyadh, Saudi Arabia
“Magnetic-guided delivery of nano gene regulators as potent breast cancer therapeutics”
14:20-14:50 Keynote Speaker: Prof. Rita Nanda MD, PhD; The University of Chicago, Chicago, IL
“Enhancing Checkpoint Inhibitors in Breast Cancer”
14:50-15:10 Speaker: Dr. Adhar Al-Sayed, MD; KFSH&RC, Riyadh, Saudi Arabia
“Combination of anti-PDL-1 with chemotherapy: Update on durvalumab and paclitaxel trial”
15:10-15:30 Speaker: Dr. Hazem Ghebeh, PhD; KFSH&RC, Riyadh, Saudi Arabia
“PDL-1 as a target for highly tumorigenic breast cancer cells”
15:30-15:40 Short Talk: Ms. Fatimah A. Mansour, MSc, KAIMRC, Riyadh, Saudi Arabia
“PD-L1 Expression in Breast Cancer Stem Cells”
15:40-16:00 Discussion and Closing Remarks
Announcement of Poster Winners